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Article Dans Une Revue Communications Biology Année : 2020

Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues

Asma Ayari
  • Fonction : Auteur
Manuel Rosa-Calatrava
  • Fonction : Auteur
Johanna Barthelemy
  • Fonction : Auteur
Andrés Pizzorno
Alicia Mayeuf-Louchart
  • Fonction : Auteur
Morgane Baron
  • Fonction : Auteur
David Hot
Lucie Deruyter
  • Fonction : Auteur
Daphnée Soulard
  • Fonction : Auteur
Thomas Julien
  • Fonction : Auteur
Christelle Faveeuw
Olivier Molendi-Coste
  • Fonction : Auteur
David Dombrowicz
  • Fonction : Auteur
Valentin Sencio
Ronan Le Goffic
François Trottein
  • Fonction : Auteur
Isabelle Wolowczuk

Résumé

Abstract Like all obligate intracellular pathogens, influenza A virus (IAV) reprograms host cell’s glucose and lipid metabolism to promote its own replication. However, the impact of influenza infection on white adipose tissue (WAT), a key tissue in the control of systemic energy homeostasis, has not been yet characterized. Here, we show that influenza infection induces alterations in whole-body glucose metabolism that persist long after the virus has been cleared. We report depot-specific changes in the WAT of IAV-infected mice, notably characterized by the appearance of thermogenic brown-like adipocytes within the subcutaneous fat depot. Importantly, viral RNA- and viral antigen-harboring cells are detected in the WAT of infected mice. Using in vitro approaches, we find that IAV infection enhances the expression of brown-adipogenesis-related genes in preadipocytes. Overall, our findings shed light on the role that the white adipose tissue, which lies at the crossroads of nutrition, metabolism and immunity, may play in influenza infection.

Dates et versions

hal-04397678 , version 1 (16-01-2024)

Identifiants

Citer

Asma Ayari, Manuel Rosa-Calatrava, Steve Lancel, Johanna Barthelemy, Andrés Pizzorno, et al.. Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues. Communications Biology, 2020, 3 (1), pp.237. ⟨10.1038/s42003-020-0965-6⟩. ⟨hal-04397678⟩
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