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A druggable copper-signalling pathway that drives inflammation

Stéphanie Solier , Sebastian Müller , Tatiana Cañeque , Antoine Versini , Arnaud Mansart , et al.
Nature, 2023, 617 (7960), pp.386-394. ⟨10.1038/s41586-023-06017-4⟩
Journal articles inserm-04170826v1
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Large scale screening discovers clofoctol as an inhibitor of SARS-CoV-2 replication that reduces COVID-19-like pathology

Sandrine Belouzard , Arnaud Machelart , Valentin Sencio , Thibaut Vausselin , Eik Hoffmann , et al.
2021
Preprints, Working Papers, ... hal-03357964v1
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Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease severity in hamsters

Valentin Sencio , Arnaud Machelart , Cyril Robil , Nicolas Benech , Eik Hoffmann , et al.
Gut microbes, 2021, 14 (1), ⟨10.1080/19490976.2021.2018900⟩
Journal articles hal-03518769v1
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Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection

Ranin Beshara , Valentin Sencio , Daphnée Soulard , Adeline Barthélémy , Josette Fontaine , et al.
PLoS Pathogens, 2018, 14 (10), pp.e1007360. ⟨10.1371/journal.ppat.1007360⟩
Journal articles inserm-02078841v1
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Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues

Asma Ayari , Manuel Rosa-Calatrava , Steve S. Lancel , Johanna Barthelemy , Andrés Pizzorno , et al.
Communications Biology, 2020, 3 (1), ⟨10.1038/s42003-020-0965-6⟩
Journal articles hal-02959942v2
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The lung–gut axis during viral respiratory infections: the impact of gut dysbiosis on secondary disease outcomes

Valentin Sencio , Marina Gomes Machado , François Trottein
Mucosal Immunology, 2021, 14 (2), pp.296-304. ⟨10.1038/s41385-020-00361-8⟩
Journal articles inserm-03385636v1
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Short-Chain Fatty Acids as a Potential Treatment for Infections: a Closer Look at the Lungs

Marina Gomes Machado , Valentin Sencio , François Trottein
Infection and Immunity, 2021, 89 (9), pp.e0018821. ⟨10.1128/IAI.00188-21⟩
Journal articles inserm-03385656v1
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The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

Jan Wenzel , Josephine Lampe , Helge Müller-Fielitz , Raphael Schuster , Marietta Zille , et al.
Nature Neuroscience, 2021, 24 (11), pp.1522-1533. ⟨10.1038/s41593-021-00926-1⟩
Journal articles inserm-03741941v1
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Toll-like receptor 5 agonist flagellin reduces influenza A virus replication independently of type I interferon and interleukin 22 and improves antiviral efficacy of oseltamivir

Anne-France Georgel , Delphine Cayet , Andrés Pizzorno , Manuel Rosa-Calatrava , Christophe Paget , et al.
Antiviral Research, 2019, 168, pp.28-35. ⟨10.1016/j.antiviral.2019.05.002⟩
Journal articles inserm-02144074v1

Bacterial immunogenic α-galactosylceramide identified in the murine large intestine: dependency on diet and inflammation

Johanna von Gerichten , Dominic Lamprecht , Lukáš Opálka , Daphnée Soulard , Christian Marsching , et al.
Journal of Lipid Research, 2019, 60 (11), pp.1892-1904. ⟨10.1194/jlr.RA119000236⟩
Journal articles hal-02398290v1
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Description of a Newly Isolated Blautia faecis Strain and Its Benefit in Mouse Models of Post-Influenza Secondary Enteric and Pulmonary Infections

Sophie Verstraeten , Valentin Sencio , Audrey Raise , Eugénie Huillet , Séverine Layec , et al.
Nutrients, 2022, 14 (7), pp.1478. ⟨10.3390/nu14071478⟩
Journal articles hal-03649191v1
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Influenza Virus Infection Impairs the Gut’s Barrier Properties and Favors Secondary Enteric Bacterial Infection through Reduced Production of Short-Chain Fatty Acids

Valentin Sencio , Alexandre Gallerand , Marina Gomes Machado , Lucie Deruyter , Séverine Heumel , et al.
Infection and Immunity, 2021, 89 (9), ⟨10.1128/IAI.00734-20⟩
Journal articles inserm-03385672v1
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Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

Sandrine Belouzard , Arnaud Machelart , Valentin Sencio , Thibaut Vausselin , Eik Hoffmann , et al.
Journal articles hal-03736399v1

Evidence that SARS-CoV-2 Induces Lung-Cell Senescence: Potential Impact on COVID-19 Lung Disease

Larissa Lipskaia , Pauline Maisonnasse , Charles Fouillade , Valentin Sencio , Quentin Pascal , et al.
American Journal of Respiratory Cell and Molecular Biology, In press, ⟨10.1165/rcmb.2021-0205LE⟩
Journal articles hal-03411265v1
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Evidence that SARS-CoV-2 Induces Lung-Cell Senescence: Potential Impact on COVID-19 Lung Disease

Larissa Lipskaia , Pauline Maisonnasse , Charles Fouillade , Valentin Sencio , Quentin Pascal , et al.
American Journal of Respiratory Cell and Molecular Biology, 2021, ⟨10.1165/rcmb.2021-0205le⟩
Journal articles hal-03395181v1
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Impact du microbiote intestinal sur les surinfections bactériennes post-grippales

Valentin Sencio
Médecine humaine et pathologie. Université de Lille, 2020. Français. ⟨NNT : 2020LILUS030⟩
Theses tel-03349638v1
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A photoactivable natural product with broad antiviral activity against enveloped viruses including highly pathogenic coronaviruses

Thomas Meunier , Lowiese Desmarets , Simon Bordage , Moussa Bamba , Kévin Hervouet , et al.
Antimicrobial Agents and Chemotherapy, 2022, ⟨10.1128/AAC.01581-21⟩
Journal articles hal-03447751v1
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Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production

Valentin Sencio , Adeline Barthélémy , Luciana Tavares , Marina Machado , Daphnée Soulard , et al.
Cell Reports, 2020, 30 (9), pp.2934-2947.e6. ⟨10.1016/j.celrep.2020.02.013⟩
Journal articles inserm-02501395v1

Interleukin-22 Immunotherapy during Severe Influenza Enhances Lung Tissue Integrity and Reduces Secondary Bacterial Systemic Invasion

Adeline Barthélémy , Valentin Sencio , Daphnée Soulard , Lucie Deruyter , Christelle Faveeuw , et al.
Infection and Immunity, 2018, 86 (7), pp.e00706-17. ⟨10.1128/IAI.00706-17⟩
Journal articles hal-02398322v1
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SARS-CoV-2 infection in nonhuman primates alters the composition and functional activity of the gut microbiota

Harry Sokol , Vanessa Contreras , Pauline Maisonnasse , Aurore Desmons , Benoit Delache , et al.
Gut microbes, 2021, 13 (1), pp.1 - 19. ⟨10.1080/19490976.2021.1893113⟩
Journal articles hal-03172042v1
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Diet-Induced Obesity and NASH Impair Disease Recovery in SARS-CoV-2-Infected Golden Hamsters

François Briand , Valentin Sencio , Cyril Robil , Séverine Heumel , Lucie Deruyter , et al.
Viruses, 2022, 14 (9), pp.2067. ⟨10.3390/v14092067⟩
Journal articles inserm-03818686v1
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Interaction between Bacteria and the Immune System for Cancer Immunotherapy: The α-GalCer Alliance

Arsenij Ustjanzew , Valentin Sencio , François Trottein , Jörg Faber , Roger Sandhoff , et al.
International Journal of Molecular Sciences, 2022, 23 (11), pp.5896. ⟨10.3390/ijms23115896⟩
Journal articles inserm-03741911v1