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Article Dans Une Revue Journal of Clinical Immunology Année : 2023

Neutrophil Activation and Immune Thrombosis Profiles Persist in Convalescent COVID-19

Hakim Hocini (1) , Aurélie Wiedemann (1) , Fabiola Blengio (1) , Cécile Lefebvre (1) , Minerva Cervantes-Gonzalez (2, 3) , Emile Foucat (1) , Pascaline Tisserand (1) , Mathieu Surenaud (1) , Séverin Coléon (1) , Mélanie Prague (4, 5, 6) , Lydia Guillaumat (1) , Corinne Krief (1) , Craig Fenwick (7) , Cédric Laouénan (2, 3) , Lila Bouadma (3) , Jade Ghosn (3, 8) , Giuseppe Pantaleo (1, 7) , Rodolphe Thiébaut (4, 5) , Laurent Abel (9) , Amal Abrous (9) , Claire Andrejak (9) , François Angoulvant (9) , Delphine Bachelet (9) , Marie Bartoli (9) , Sylvie Behilill (9) , Marine Beluze (9) , Krishna Bhavsar (9) , Anissa Chair (9) , Charlotte Charpentier (9) , Léo Chenard (9) , Catherine Chirouze (9) , Sandrine Couffin-Cadiergues (9) , Camille Couffignal (9) , Nathalie De Castro (9) , Marie-Pierre Debray (9) , Dominique Deplanque (9) , Diane Descamps (9) , Alpha Diallo (9) , Fernanda Dias Da Silva (9) , Céline Dorival (9) , Xavier Duval (9) , Philippine Eloy (9) , Vincent Enouf (9) , Hélène Esperou (9) , Marina Esposito-Farese (9) , Manuel Etienne (9) , Aline-Marie Florence (9) , Alexandre Gaymard (9) , Tristan Gigante (9) , Morgane Gilg (9) , François Goehringer (9) , Jérémie Guedj (9) , Ikram Houas (9) , Isabelle Hoffmann (9) , Jean-Sébastien Hulot (9) , Salma Jaafoura (9) , Simon Jamard (9) , Ouifiya Kafif (9) , Antoine Khalil (9) , Nadhem Lafhej (9) , Samira Laribi (9) , Minh Le (9) , Quentin Le Hingrat (9) , Soizic Le Mestre (9) , Sophie Letrou (9) , Bruno Lina (9) , Guillaume Lingas (9) , Denis Malvy (9) , France Mentré (9) , Hugo Mouquet (9) , Nadège Neant (9) , Christelle Paul (9) , Aurélie Papadopoulos (9) , Ventzislava Petrov-Sanchez (9) , Gilles Peytavin (9) , Valentine Piquard (9) , Olivier Picone (9) , Manuel Rosa-Calatrava (9) , Bénédicte Rossignol (9) , Patrick Rossignol (9) , Carine Roy (9) , Marion Schneider (9) , Coralie Tardivon (9) , Jean-François Timsit (9) , Sarah Tubiana (9) , Sylvie Van. Der Werf (9) , Benoit Visseaux (9) , Yves Lévy (10)
Claire Andrejak
Catherine Chirouze
Yves Lévy
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Résumé

Purpose Following a severe COVID-19 infection, a proportion of individuals develop prolonged symptoms. We investigated the immunological dysfunction that underlies the persistence of symptoms months after the resolution of acute COVID-19. Methods We analyzed cytokines, cell phenotypes, SARS-CoV-2 spike-specific and neutralizing antibodies, and whole blood gene expression profiles in convalescent severe COVID-19 patients 1, 3, and 6 months following hospital discharge. Results We observed persistent abnormalities until month 6 marked by (i) high serum levels of monocyte/macrophage and endothelial activation markers, chemotaxis, and hematopoietic cytokines; (ii) a high frequency of central memory CD4 + and effector CD8 + T cells; (iii) a decrease in anti-SARS-CoV-2 spike and neutralizing antibodies; and (iv) an upregulation of genes related to platelet, neutrophil activation, erythrocytes, myeloid cell differentiation, and RUNX1 signaling. We identified a “core gene signature” associated with a history of thrombotic events, with upregulation of a set of genes involved in neutrophil activation, platelet, hematopoiesis, and blood coagulation. Conclusion The lack of restoration of gene expression to a normal profile after up to 6 months of follow-up, even in asymptomatic patients who experienced severe COVID-19, signals the need to carefully extend their clinical follow-up and propose preventive measures.
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Dates et versions

hal-04373844 , version 1 (09-01-2024)

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Hakim Hocini, Aurélie Wiedemann, Fabiola Blengio, Cécile Lefebvre, Minerva Cervantes-Gonzalez, et al.. Neutrophil Activation and Immune Thrombosis Profiles Persist in Convalescent COVID-19. Journal of Clinical Immunology, 2023, 43 (5), pp.882-893. ⟨10.1007/s10875-023-01459-x⟩. ⟨hal-04373844⟩
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