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Article Dans Une Revue NMR in Biomedicine Année : 2020

Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations

Alireza Abaei
Olivier Braissant
In‐young Choi
Cristina Cudalbu
Pierre‐gilles Henry
  • Fonction : Auteur
Firat Kara
  • Fonction : Auteur
Kejal Kantarci
  • Fonction : Auteur
Phil Lee
Małgorzata Marjańska
Vladimír Mlynárik
  • Fonction : Auteur
Volker Rasche
  • Fonction : Auteur
Lijing Xin
  • Fonction : Auteur

Résumé

In vivo MRS is a non‐invasive measurement technique used not only in humans, but also in animal models using high‐field magnets. MRS enables the measurement of metabolite concentrations as well as metabolic rates and their modifications in healthy animals and disease models. Such data open the way to a deeper understanding of the underlying biochemistry, related disturbances and mechanisms taking place during or prior to symptoms and tissue changes. In this work, we focus on the main preclinical 1 H, 31 P and 13 C MRS approaches to study brain metabolism in rodent models, with the aim of providing general experts’ consensus recommendations (animal models, anesthesia, data acquisition protocols). An overview of the main practical differences in preclinical compared with clinical MRS studies is presented, as well as the additional biochemical information that can be obtained in animal models in terms of metabolite concentrations and metabolic flux measurements. The properties of high‐field preclinical MRS and the technical limitations are also described.
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Dates et versions

hal-04372367 , version 1 (04-01-2024)

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Bernard Lanz, Alireza Abaei, Olivier Braissant, In‐young Choi, Cristina Cudalbu, et al.. Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations. NMR in Biomedicine, 2020, 34 (5), ⟨10.1002/nbm.4325⟩. ⟨hal-04372367⟩
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