Differentiation of synthetic sources of an organophosphorus chemical by LC-HRMS-based metabolomics
Résumé
Chemical attribution signatures for chemical threat agents can be used to provide an evidentiary link between the use of a given chemical and its origin to support forensic investigations. Complementary to specific targeted compounds detection, untargeted approaches combined with multivariate analyses can provide further information to determine the source or the synthetic pathways. Organophosphorous compounds used as nerve agents, can be produced by more or less complex synthesis routes. To assess the specificity of by-products, impurities, and others compounds originated from a chemical synthesis, untargeted fingerprints of crude chlorpyrifos (CPF) from different synthesis ways were analyzed as a first use-case using metabolomics-based trace discovery strategies
Domaines
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