Respiratory rhythm modulates membrane potential and spiking of non-olfactory neurons - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Neurophysiology Année : 2023

Respiratory rhythm modulates membrane potential and spiking of non-olfactory neurons

Résumé

In recent years, several studies have shown a respiratory drive of the local field potential (LFP) in numerous brain areas so that the respiratory rhythm could be considered as a master clock promoting communication between distant brain locations. However, outside of the olfactory system, it remains unknown whether the respiratory rhythm could shape membrane potential (MP) oscillations. To fill this gap, we co-recorded MP and LFP activities in different nonolfactory brain areas, medial prefrontal cortex (mPFC), primary somatosensory cortex (S1), primary visual cortex (V1), and hippocampus (HPC), in urethane-anesthetized rats. Using respiratory cycle-by-cycle analysis, we observed that respiration could modulate both MP and spiking discharges in all recorded areas during episodes that we called respiration-related oscillations (RRo). Further quantifications revealed that RRo episodes were transient in most neurons (5 consecutive respiratory cycles in average). RRo development in MP was largely correlated with the presence of respiratory modulation in the LFP. By showing that the respiratory rhythm influenced brain activities deep to the MP of nonolfactory neurons, our data support the idea that respiratory rhythm could mediate long-range communication between brain areas.NEW & NOTEWORTHY In this study, we evidenced strong respiratory-driven oscillations of neuronal membrane potential and spiking discharge in various nonolfactory areas of the mammal brain. These oscillations were found in the medial prefrontal cortex, primary somatosensory cortex, primary visual cortex, and hippocampus. These findings support the idea that respiratory rhythm could be used as a common clock to set the dynamics of large-scale neuronal networks on the same slow rhythm.
Fichier principal
Vignette du fichier
juventin-et-al-2023-respiratory-rhythm-modulates-membrane-potential-and-spiking-of-non-olfactory-neurons.pdf (7.57 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Licence : CC BY - Paternité

Dates et versions

hal-04335818 , version 1 (11-12-2023)

Licence

Paternité

Identifiants

Citer

Maxime Juventin, Mickael Zbili, Nicolas Fourcaud-Trocmé, Samuel Garcia, Nathalie Buonviso, et al.. Respiratory rhythm modulates membrane potential and spiking of non-olfactory neurons. Journal of Neurophysiology, 2023, 130 (6), pp.1552-1566. ⟨10.1152/jn.00487.2022⟩. ⟨hal-04335818⟩
21 Consultations
40 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More