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Poster De Conférence Année : 2023

Sex specific impact of perinatal exposure to 3500 MHz 5G frequency on the rat stereotyped behavior

Résumé

The 5G electromagnetic field (EMF) network is currently being worldwide spread out. It raises concerns on the potential effects of radiofrequency on neurodevelopment. During the perinatal period, the organism is immature. Its skin and skull are thinner than in adults and less effective at preventing EMF penetration [1]. In addition, research is now focusing about the impact of the perinatal environmental exposome on maternal, fetal, and neonatal health outcomes. This concept is called the Developmental Origins of Health and Disease (DOHaD) [2],[3]. The current study aimed to investigate the effects of daily 5G EMF exposure in the rat (n=7) from gestational day 8 to post-natal day (PND) 21. The exposure level aimed to mimic the limit of whole-body public exposure set by the International Commission on Non-Ionizing Radiation Protection (ICNIRP, 0.08 W/kg). Specific absorption rate was 0.07 W/kg for 22h/day at 3.5 GHz continuous wave (CW). Clinical observations were performed on weight, length, sex ratio, number of pups per litter and number of stillborn in sham and EMF exposed groups. The age of pinna ear detachment, incisors eruption and eyes opening were recorded. Behavioral data were also collected on righting, gripping and negative geotaxis reflexes at PND 3 or 7 and for stereotyped and horizontal movements in the open field at PND 21 and 43. Our results indicated that both male and female pups showed delayed incisor eruption (1 more day ; p-value = 0.015 and 0.020) in the EMF exposed group compared to the sham group. Regarding stereotypic movements, females showed less activity (-60% at PND 21, p-value = 0.0015 ; and PND 43, p-value<0.0001) and males, more (+30% at PND 43, p-value = 0.0037) compared to the sham group. No significative results were observed in other parameters studied.Thus, the present study suggests that perinatal exposure to CW-EMF leads to clinical and behavioral perturbations with sex specific effects. References [1] Rodier, Patricia M. 1995 'Developing Brain as a Target of Toxicity.' Environmental Health Perspectives, vol. 103, , pp. 73–76. JSTOR [2] Rager Julia E. 2020 , Review of the environmental prenatal exposome and its relationship to maternal and fetal health. Reprod Toxicol. 2020 Dec;98:1-12. doi: 10.1016/j.reprotox.2020.02.004. [3] Daniel J. Hoffman 2017 Developmental origins of health and disease: current knowledge and potential mechanisms. Nutr Rev. 2017 Dec 1;75(12):951-970. doi: 10.1093/nutrit/nux053.
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Dates et versions

hal-04329491 , version 1 (11-12-2023)

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  • HAL Id : hal-04329491 , version 1

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Raphaël Bodin, Chandreshwar Seewooruttun, Aurélie Corona, Stéphane Delanaud, Amandine Pelletier, et al.. Sex specific impact of perinatal exposure to 3500 MHz 5G frequency on the rat stereotyped behavior. Eurotox 2023, Sep 2023, Ljubljana, Slovenia. ⟨hal-04329491⟩

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