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Poster De Conférence Année : 2022

Non-volatile substances extractible from inner coatings of metallic cans from the French market and their occurrence in the canned vegetables

Résumé

Introduction Regulatory pressure against bisphenol A for food contact material (FCM) applications led can coating manufacturers to develop polyester-based alternatives. Besides intentionally added substances, the investigation of the presence of non-intentionally added substances (NIAS) has been raising the interest of the scientific community in response to manufacturers and consumers concerns. NIAS, generally of unknown structures, can be impurities from starting materials, degradation or decomposition products, contaminants from production process or oligomers principally formed during the synthesis of the coating. Such oligomers can be formed during resin synthesis or upon degradation over time. Although a wide range of reactions are possible (which poses an analytical challenge), these NIAS may be predicted since polyalcohols and carboxylic polyacids involved in the polycondensation reaction are generally known. In order to increase chemical food safety of packaging, it is now necessary to produce qualitative, quantitative and toxicological data. This work aimed to contribute to the risk assessment of NIAS from polyester-based coatings by developing an innovative analytical strategy dedicated to their characterisation. Materials and methods A comprehensive database of predictable oligoesters was developed based on known monomers. Combined with the acquisition of a fingerprint from polyester resins extracts by LC/HRMS coupling, it allowed for the annotation of the signals of interest. Eventually, previously unavailable genuine analytical standards were synthetized, including linear and cyclic, native and deuterium-labelled combinations of neopentyl glycol and isophtalic acid (lengths of 4 and 8 monomers), allowing structure identification at the highest level of confidence and semi quantification. Results and Discussion The developed methodology allowed to pinpoint more than 125 compounds in a set of 40 coatings from 12 vegetable cans sampled in a supermarket. Among the 75 oligoester combinations (involving 6 diols and 4 diacids) identified in the coatings, 61 migrated to the can contents. Cumulative semi-quantification levels averaged 330 ng/g in the drained vegetables (43 to 1600 ng/g). Minor identified NIAS included (i) BADGE derivatives that were not expected, (ii) phenolic oligomers and (iii) benzoguanamine derivatives described for the first time. Conclusion Using a non-targeted LC/ESI(+)-HRMS approach, dozens of small molecules in inner coatings of vegetable metallic cans have been identified. Oligoesters, a diverse family of unwanted compounds arising from the synthesis of polyesters, prevailed in the data set. This study sheds light on the need to fulfil a proper risk assessment on this NIAS family (exposure and hazard characterisation, including genotoxicity and endocrine disruption).
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Dates et versions

hal-04320992 , version 1 (04-12-2023)

Identifiants

  • HAL Id : hal-04320992 , version 1

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Matthieu Rivière, Ronan Cariou, Sébastien Hutinet, Asmaa Tebbaa, Yann Guitton, et al.. Non-volatile substances extractible from inner coatings of metallic cans from the French market and their occurrence in the canned vegetables. Analytics 2022, Sep 2022, Nantes, France. 2022. ⟨hal-04320992⟩
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