Acoustic streaming in bone pericellular fluid under ultrasound stimulation
Résumé
The use of ultrasound (US) stimulation for bone healing is a therapeutic approach that dates back over half a century. Nevertheless, the therapeutic efficacy of US stimulation of bone remodelling remains an open question, as the underlying mechanisms involved are still poorly understood. Among the possible hypotheses, the propagation of ultrasonic waves in bone tissue could generate acoustic streaming (AS) resulting in fluid shear stress exerted on the wall of osteocytes known as the mechanosensitive conductors of bone remodeling. Osteocytes are dendritic cells surrounded by a viscous pericellular fluid (PCF), ubiquituous in the bone extra-cellular matrix (ECM) forming a complex micrometric 3D network called the lacuno-canalicular network (LCN). A first finite-element (FE) model is proposed to investigate the AS induced by a US stimulation inside the PCF considered as a viscous fluid. The resulting wall shear stress (WSS) applied on the osteocyte process is estimated for different shapes of PCF space and different viscosities of PCF.
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