Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups - Archive ouverte HAL
Article Dans Une Revue Nature Communications Année : 2023

Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups

María-Jesús Lobón-Iglesias
  • Fonction : Auteur
Sandrina Turczynski
Gaelle Pierron
Laetitia Maillot
  • Fonction : Auteur
Christine Bourneix
  • Fonction : Auteur
Célio Pouponnot
Mylene Bohec
Sylvain Baulande
Olivier Delattre
Eliane Piaggio
Olivier Ayrault
Joshua Waterfall
Nicolas Servant
Kevin Beccaria
  • Fonction : Auteur
Volodia Dangouloff-Ros
Franck Bourdeaut

Résumé

Abstract Atypical teratoid rhabdoid tumors (ATRT) are divided into MYC, TYR and SHH subgroups, suggesting diverse lineages of origin. Here, we investigate the imaging of human ATRT at diagnosis and the precise anatomic origin of brain tumors in the Rosa26-Cre ERT2 ::Smarcb1 flox/flox model. This cross-species analysis points to an extra-cerebral origin for MYC tumors. Additionally, we clearly distinguish SHH ATRT emerging from the cerebellar anterior lobe (CAL) from those emerging from the basal ganglia (BG) and intra-ventricular (IV) regions. Molecular characteristics point to the midbrain-hindbrain boundary as the origin of CAL SHH ATRT, and to the ganglionic eminence as the origin of BG/IV SHH ATRT. Single-cell RNA sequencing on SHH ATRT supports these hypotheses. Trajectory analyses suggest that SMARCB1 loss induces a de-differentiation process mediated by repressors of the neuronal program such as REST , ID and the NOTCH pathway.

Dates et versions

hal-04295076 , version 1 (20-11-2023)

Identifiants

Citer

María-Jesús Lobón-Iglesias, Mamy Andrianteranagna, Zhi-Yan Han, Céline Chauvin, Julien Masliah-Planchon, et al.. Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups. Nature Communications, 2023, 14 (1), pp.6669. ⟨10.1038/s41467-023-42371-7⟩. ⟨hal-04295076⟩
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