We present the derivation of upwind numerical fluxes for the space discontinuous Galerkin (dG) finite element method applied to the numerical modeling of wave propagation in multidimensional coupled acoustic/elastic media. The space dG method is formulated using the first-order velocity-pressure and velocity-stress systems for acoustic and elastic media, respectively. After eigenanalysis of the first-order hyperbolic systems highlighting the eigenmodes of wave propagation, the upwind numerical fluxes on the acoustic/acoustic and acoustic/elastic interface are obtained in terms of exact solutions of relevant Riemann problems. Thanks to the proposed approach, explicit closed-form expressions of the upwind numerical fluxes are obtained on the acoustic/elastic interface for the general case of multidimensional anisotropic heterogeneous solid media coupled with acoustic fluids. The developed numerical fluxes are validated by analytical/numerical comparison considering the example of an acoustic domain with a circular elastic inclusion. Finally, the coupled solver is used to perform a multiparametric study on the microstructure’s echogenicity in a 3D-printed synthetic material under ultrasonic imaging.