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Article Dans Une Revue ACS Applied Nano Materials Année : 2023

Internalization of Pegylated Er:Y2O3 Nanoparticles inside HCT-116 Cancer Cells: Implications for Imaging and Drug Delivery

Angela Caponnetto
Valérie Marchi

Résumé

Lanthanide-doped nanoparticles, featuring sharp emission peaks with narrow bandwidth, exhibit high downconversion luminescence intensity, making them highly valuable in the fields of bioimaging and drug delivery. High-crystallinity Y2O3 nanoparticles (NPs) doped Er3+ ions were functionalized by using a pegylation procedure to confer water solubility biocompatibility. The NPs thoroughly characterized transmission electron microscopy (TEM), inductively coupled plasma mass spectrometry (ICP-MS), photoluminescence measurements. pegylated studied both from toxicological perspective demonstrate their internalization within HCT-116 cancer cells. Cell viability tests allowed for identification “optimal” concentration, which yields detectable fluorescence signal without being toxic process was investigated combined approach involving confocal ICP-MS. obtained data clearly indicate efficient into cells intensity showing strong correlation concentrations delivered Overall, this research contributes significantly nanotechnology biomedical research, noteworthy implications imaging delivery applications.
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hal-04261571 , version 1 (06-11-2023)

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Regina Maria Chiechio, Angela Caponnetto, Rosalia Battaglia, Carmen Ferrara, Ester Butera, et al.. Internalization of Pegylated Er:Y2O3 Nanoparticles inside HCT-116 Cancer Cells: Implications for Imaging and Drug Delivery. ACS Applied Nano Materials, 2023, 6 (20), pp.19126-19135. ⟨10.1021/acsanm.3c03609⟩. ⟨hal-04261571⟩
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