Internalization of Pegylated Er:Y2O3 Nanoparticles inside HCT-116 Cancer Cells: Implications for Imaging and Drug Delivery
Résumé
Lanthanide-doped nanoparticles, featuring sharp emission peaks with narrow bandwidth, exhibit high downconversion luminescence intensity, making them highly valuable in the fields of bioimaging and drug delivery. High-crystallinity Y2O3 nanoparticles (NPs) doped Er3+ ions were functionalized by using a pegylation procedure to confer water solubility biocompatibility. The NPs thoroughly characterized transmission electron microscopy (TEM), inductively coupled plasma mass spectrometry (ICP-MS), photoluminescence measurements. pegylated studied both from toxicological perspective demonstrate their internalization within HCT-116 cancer cells. Cell viability tests allowed for identification “optimal” concentration, which yields detectable fluorescence signal without being toxic process was investigated combined approach involving confocal ICP-MS. obtained data clearly indicate efficient into cells intensity showing strong correlation concentrations delivered Overall, this research contributes significantly nanotechnology biomedical research, noteworthy implications imaging delivery applications.
Mots clés
Internalization
Biocompatibility
Nanoparticle
Nanotechnology
Drug delivery
Materials science
Confocal microscopy
Photoluminescence
PEGylation
Luminescence
Transmission electron microscopy
Crystallinity
Chemistry
Polyethylene glycol
Cell
Optoelectronics
Organic chemistry
Biochemistry
Optics
Physics
Metallurgy
Composite material
Domaines
Chimie thérapeutique
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chiechio-et-al-2023-internalization-of-pegylated-er-y2o3-nanoparticles-inside-hct-116-cancer-cells-implications-for.pdf (4.16 Mo)
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