Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half‐Sandwich Ruthenium and Osmium Complexes - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Helvetica Chimica Acta Année : 2023

Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half‐Sandwich Ruthenium and Osmium Complexes

Joan Soldevila-Barreda
Maria Azmanova
Laia Rafols
Amr Attia
Alexandru Lupan
Luca Ronconi
Nicolas Barry

Résumé

The synthesis by transmetallation and in‐depth characterisation by IR spectroscopy of five half‐sandwich ruthenium and osmium dithiocarbamato isonipecotamide glycoconjugate complexes are presented herein. The evaluation of their in vitro cytotoxicity and of the zinc precursors’ in vitro cytotoxicity towards ovarian cancer (A2780 and A2780cisR) and normal prostate (PNT2) cells is reported. While the cytotoxicity of the compounds is rather limited, some selectivity is observed.

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Chimie
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Dates et versions

hal-04245105 , version 1 (16-10-2023)

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Joan Soldevila-Barreda, Andrea Pettenuzzo, Maria Azmanova, Laia Rafols, Amr Attia, et al.. Synthesis, Characterisation, and in vitro Cytotoxic Activity of Dithiocarbamato Glycoconjugate Half‐Sandwich Ruthenium and Osmium Complexes. Helvetica Chimica Acta, 2023, 106 (8), pp.e202300064. ⟨10.1002/hlca.202300064⟩. ⟨hal-04245105⟩
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