Prenatal systemic hypoxiaischemia: A rat model of neurodevelopmental disorders related to prematurity
Résumé
Premature birth represents about 11% of pregnancies overall and is increasing worldwide. The prevalence of brain damage and neurodevelopmental disorders (NDDs) related to prematurity is high and increasing. Etiological factors of perinatal brain injury in preterm children mainly involve exposure to systemic infection/inflammation, hypoxia/ischemia or hyperoxia, placental pathologies, foetal growth restriction or infections, maternal hypotension, hypoxemia, preeclampsia, diabetes, as well as multiple birth, stress, air pollution or drug abuse. Several animal models have been developped to better understand the perinatal etiological factors and mechanisms underlying the emergence of NDDs. Among rat models of prenatal brain injury, mild intrauterine hypoperfusion (MIUH) at embryonic day 17 (E17), transient systemic hypoxia-ischemia (TSHI) at E18, reduced uterine perfusion pressure (RUPP) from E14 and permanent stenosis of uterine arteries at E17 using ameroid constrictors (AC) are gathered here as prenatal systemic hypoxia-ischemia (PSHI). Briefly, these models of PSHI induce intrauterine growth restriction, low birth weight, cardiovascular disease, metabolic syndrome, neuroinflammation, diffuse brain damage including white and gray matter injuries, astrogliosis, hyperexcitability related to homeostatic imbalance of intracellular chloride concentration, musculoskeletal pathologies, sensorimotor disturbances, impaired behavior and cognition, and deficits in executive functions related to maladaptive plasticity and network disorganization in the central nervous system (CNS). These preclinical models point out several mechanisms of action and are promising for developing new strategies of prevention, remediation and rehabilitation of the NDDs related to prematurity.
Mots clés
GABA
gamma-aminobutyric acid
HI
hypoxia-ischemia
IUGR
intrauterine growth restriction
LBW
KCC2
potassium-chloride cotransporter 2
MIUH
NKCC1
sodiumpotassium-chloride cotransporter 1
NDDs
neurodevelopmental disorders
P10
postnatal day 10
PSHI
prenatal systemic hypoxia-ischemia
RUPP
TSHI
WMI
(5-10) intrauterine growth restriction
mild intrauterine hypoperfusion
reduced uterine perfusion pressure
transient systemic hypoxia-ischemia
low birth weight
white matter injury
hyperactivity
neuroinflammation
maladaptive plasticity
hyperexcitability AC
ameroid constrictors ADHD
attention deficit hyperactivity disorder ASD
autism spectrum disorder EP
encephalopathy of prematurity E17
embryonic day 17 GABA
gamma-aminobutyric acid HI
hypoxia-ischemia IUGR
intrauterine growth restriction LBW
low birth weight KCC2
potassium-chloride cotransporter 2 MIUH
mild intrauterine hypoperfusion NKCC1
sodiumpotassium-chloride cotransporter 1 NDDs
neurodevelopmental disorders P10
postnatal day 10 PSHI
prenatal systemic hypoxia-ischemia RUPP
reduced uterine perfusion pressure TSHI
transient systemic hypoxia-ischemia WMI
ameroid constrictors
ADHD
attention deficit hyperactivity disorder
ASD
autism spectrum disorder
EP
encephalopathy of prematurity
E17
embryonic day 17
Domaines
Sciences du Vivant [q-bio]
Fichier principal
Coq_Tsuji_Handbook_AniModels_MIUH_2021_4_wiFig.pdf (784 Ko)
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