BCL2L10 is a predictive factor for resistance to Azacitidine in MDS and AML patients - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Oncotarget Année : 2012

BCL2L10 is a predictive factor for resistance to Azacitidine in MDS and AML patients

Résumé

Azacitidine is the leading compound to treat patients suffering myelodysplastic syndrome (MDS) or AML with less than 30% of blasts, but a majority of patients is primary refractory or rapidly relapses under treatment. These patients have a drastically reduced life expectancy as compared to sensitive patients. Therefore identifying predictive factors for AZA resistance is of great interest to propose alternative therapeutic strategies for non-responsive patients. We generated AZA-resistant myeloid cell line (SKM1-R) that exhibited increased expression of BCL2L10 an anti-apoptotic Bcl-2 family member. Importantly, BCL2L10 knockdown sensitized SKM1-R cells to AZA effect suggesting that increased BCL2L10 expression is linked to AZA resistance in SKM1-R. We next established in 77 MDS patients that resistance to AZA is significantly correlated with the percentage of MDS or AML cells expressing BCL2L10. In addition, we showed that the proportion of BCL2L10 positive bone marrow cells can predict overall survival in MDS or AML patients. We propose a convenient assay in which the percentage of BCL2L10 expressing cells as assessed by flow cytometry is predictive of whether or not a patient will become resistant to AZA. Therefore, systematic determination of BCL2L10 expression could be of great interest in newly diagnosed and AZA-treated MDS patients.
Fichier principal
Vignette du fichier
oncotarget-03-490.pdf (2.21 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04237691 , version 1 (11-10-2023)

Identifiants

Citer

Thomas Cluzeau, Guillaume Robert, Nicolas Mounier, Jean Michel Karsenti, Maeva Dufies, et al.. BCL2L10 is a predictive factor for resistance to Azacitidine in MDS and AML patients. Oncotarget, 2012, 3 (4), pp.490-501. ⟨10.18632/oncotarget.481⟩. ⟨hal-04237691⟩
13 Consultations
5 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More