Generation of embryo chimeras with pluripotent stem cells in rabbit - Archive ouverte HAL Accéder directement au contenu
Poster De Conférence Année : 2023

Generation of embryo chimeras with pluripotent stem cells in rabbit

Résumé

Mouse pluripotent stem-cells (PSCs) self-renew into the naïve state of pluripotency. After injection into a host mouse blastocyst, they are able to form a chimera by colonizing the host preimplantation embryo (Nagy et al., 1993). Moreover, mouse PSCs are able to form interspecies chimeras after injection into a rabbit host blastocyst (Aksoy et al., 2021). Consequently, these PSCs are the gold standard of the chimerism. Conversely, rabbit PSCs self-renew into the primed state of pluripotency. They have low colonization capacity of preimplantation embryo after injection into a host blastocyst (Osteil et al., 2016). We are investigating how rabbit PSCs can become able to generate chimeras and which mechanism are involved in this process.
Fichier non déposé

Dates et versions

hal-04219124 , version 1 (26-09-2023)

Identifiants

  • HAL Id : hal-04219124 , version 1

Citer

Yannicke Pijoff, Florence Perold, Hong Thu Pham, Thierry Joly, Nathalie Beaujean, et al.. Generation of embryo chimeras with pluripotent stem cells in rabbit. STEM CELLS IN REGENERATIVE BIOLOGY AND MEDICINE 10th Annual CONSORTIUM MEETING, Feb 2023, Chantilly-Gouvieux, France. ⟨hal-04219124⟩
29 Consultations
0 Téléchargements

Partager

Gmail Mastodon Facebook X LinkedIn More