The present work aims at investigating the oxidative dehydrogenation of propane (ODHP) catalytic properties of Co species supported on a Siβ zeolitic support. The Co2+ species incorporated in the silanol nests created by dealumination of a HAlSiβ pristine support (Co-Siβ) appeared to be about 4 times more active (3.1 × 10-3 s-1) compared with that in exchange position of HAlSiβ (0.9 ×10-3 s-1) for the formation of propene at 400 ◦C. The turn over frequency of the Co-Siβ samples are found to be greater than or equal to those reported in most of the earlier studies performed with Co-containing materials to date and to be about 7 times greater than that of V-Siβ materials (0.4 ×10-3 s-1) from an earlier study, which illustrates the superiority of Co-Siβ over V-Siβ for the ODHP reaction. Maximum incorporable content of Co as Co-Siβ is dictated by the amount of removable Al.