Biomedical Framework for Enhanced Experimentation, based on Firebase Real-Time Database, helps in designing and testing various multimodal solutions for patients suffering from progressive diseases. It allows interacting with objects and robots to test various multimodal solutions, such as touch, voice, gesture... to perform tasks according to the patient's pathology. We tested BIOFEE with Unity3D and Webots virtual worlds to compare different ways to interact for particular tasks (switch lamps, pick and place...).