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Article Dans Une Revue Polymer Engineering and Science Année : 2023

Electrospinning of ultrafine non-hydrolyzed silk sericin/PEO fibers on PLA : a bilayer scaffold fabrication

Résumé

We report the feasibility of electrospinning of protein-polymer multilayered scaffolds with selected materials such as non-hydrolyzed silk sericin (SS), poly- ethylene oxide (PEO), and polylactic acid (PLA), with tuned fiber size and properties for each layer. We present a new innovative way for the electrospin- ning (ES) of non-hydrolyzed SS mixed with PEO yielding fibers with an aver- age diameter ranging between 120 and 150 nm. Different SS:PEO ratios have been electrospun to study the effect of the concentration of SS protein on the fibers size and shape, as well and their electrospinnability. Electrospun SS:PEO fibers display weak to no mechanical resistance (non-measurable) and their deposition onto a sturdier scaffold is necessary to allow their use in bio- medical and/or pharmaceutical fields. Therefore, bilayer scaffolds have been fabricated consisting of a PLA support and SS:PEO fibers obtained from the optimized SS:PEO ratio (1.2:4). They are composed of a sturdy hydrophobic layer of PLA fibers and a layer of sticky hydrophilic SS:PEO fibers. The scaf- folds have been characterized extensively by Fourier transforms infra-red (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and their resistance to mechanical stress. Finally, hydrophobicity of both layers has been determined by measuring the contact angle of water drop- lets on the scaffolds, further proving the bilayer nature of the scaffolds.
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Dates et versions

hal-04158440 , version 1 (25-07-2023)

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Paul Mathieu, Rémi Bascou, Francisco Sebastian Navarro Oliva, Alla Nesterenko, Anh-Tu Ngo, et al.. Electrospinning of ultrafine non-hydrolyzed silk sericin/PEO fibers on PLA : a bilayer scaffold fabrication. Polymer Engineering and Science, 2023, 63 (3), pp.830-840. ⟨10.1002/pen.26248⟩. ⟨hal-04158440⟩
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