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Communication Dans Un Congrès Année : 2023

Development of preclinical mri elastography at 7T: an original approach for the non-invasive mechanical characterization of mouse organs

Résumé

Magnetic Resonance Elastography (MRE) is a non-invasive imaging method that aims at mapping the mechanical properties of a tissue in vivo. MRE is based on 3 steps: (1) the mechanical excitation of the organ by external generation of shear waves; (2) the encoding of the sample response by MRI using specific sequences; (3) the reconstruction of the mechanical properties. In a more marginal way, MRE has been developed for preclinical studies, such as investigation of liver, brain or skeletal muscle pathologies in mice. However, few MRE setups are currently available for preclinical purpose. In the framework of a French multicenter consortium, we have recently developed an innovative and original MRE process to investigate the mechanical properties in different organs of mouse. Available at the IRIS platform of the ICube laboratory in Strasbourg, this research tool combines performances for in vivo mapping of mechanical properties .
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Dates et versions

hal-04140822 , version 1 (26-06-2023)

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  • HAL Id : hal-04140822 , version 1

Citer

Aude Loumeaud, Chrystelle Po, Gwenaël Pagé, Philippe Garteiser, Jonathan Vappou, et al.. Development of preclinical mri elastography at 7T: an original approach for the non-invasive mechanical characterization of mouse organs. Journées scientifiques de la Fédération de Médecine Translationnelle de Strasbourg (FMTS), Fédération de Médecine Translationnelle de Strasbourg; Faculté de Médecine, Maïeutique et Sciences de la Santé; Hôpitaux Universitaires de Strasbourg, Jun 2023, Strasbourg, France. ⟨hal-04140822⟩
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