Development of preclinical mri elastography at 7T: an original approach for the non-invasive mechanical characterization of mouse organs
Résumé
Magnetic Resonance Elastography (MRE) is a non-invasive imaging method that aims at mapping the mechanical properties of a tissue in vivo. MRE is based on 3 steps: (1) the mechanical excitation of the organ by external generation of shear waves; (2) the encoding of the sample response by MRI using specific sequences; (3) the reconstruction of the mechanical properties. In a more marginal way, MRE has been developed for preclinical studies, such as investigation of liver, brain or skeletal muscle pathologies in mice. However, few MRE setups are currently available for preclinical purpose. In the framework of a French multicenter consortium, we have recently developed an innovative and original MRE process to investigate the mechanical properties in different organs of mouse. Available at the IRIS platform of the ICube laboratory in Strasbourg, this research tool combines performances for in vivo mapping of mechanical properties .
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