Identification of 2-Methylthio-methylenethio-N-6-(cis-4-hydroxyisopentenyl)adenosine (msms(2)io(6)A(37)) as a Novel Modification at Adenosine 37 of tRNAs from Salmonella typhimurium - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue ChemBioChem Année : 2023

Identification of 2-Methylthio-methylenethio-N-6-(cis-4-hydroxyisopentenyl)adenosine (msms(2)io(6)A(37)) as a Novel Modification at Adenosine 37 of tRNAs from Salmonella typhimurium

Résumé

Post-transcriptional modifications of tRNA nucleotide are important determinants in folding, structure and function. We have successfully identified and characterized a new modified base named 2-methylthio-methylenethio-N-6-(cis-4-hydroxyisopentenyl)adenosine, which is present at position 37 in some tRNAs. We also showed that this new modified adenosine is derived from the known 2-methylthio-methylenethio-N-6-(isopentenyl)adenosine nucleoside by a catalytic cycle of the tRNA-diiron monooxygenase, MiaE, present in Salmonella typhimurium.
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hal-04136510 , version 1 (10-10-2023)

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Marouane Libiad, Thierry Douki, Marc Fontecave, Mohamed Atta. Identification of 2-Methylthio-methylenethio-N-6-(cis-4-hydroxyisopentenyl)adenosine (msms(2)io(6)A(37)) as a Novel Modification at Adenosine 37 of tRNAs from Salmonella typhimurium. ChemBioChem, 2023, 24 (6), pp.e202300019. ⟨10.1002/cbic.202300019⟩. ⟨hal-04136510⟩
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