Identification of 2-Methylthio-methylenethio-N-6-(cis-4-hydroxyisopentenyl)adenosine (msms(2)io(6)A(37)) as a Novel Modification at Adenosine 37 of tRNAs from Salmonella typhimurium
Résumé
Post-transcriptional modifications of tRNA nucleotide are important determinants in folding, structure and function. We have successfully identified and characterized a new modified base named 2-methylthio-methylenethio-N-6-(cis-4-hydroxyisopentenyl)adenosine, which is present at position 37 in some tRNAs. We also showed that this new modified adenosine is derived from the known 2-methylthio-methylenethio-N-6-(isopentenyl)adenosine nucleoside by a catalytic cycle of the tRNA-diiron monooxygenase, MiaE, present in Salmonella typhimurium.
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ChemBioChem - 2023 - Libiad - Identification of 2‐Methylthio‐methylenethio‐N6‐ cis‐4‐hydroxyisopentenyl adenosine .pdf (504.9 Ko)
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