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Article Dans Une Revue Journal of Physical Chemistry Letters Année : 2023

Enantiomeric Excesses of Aminonitrile Precursors Determine the Homochirality of Amino Acids

Résumé

High enantiomeric excesses (ee’s) of L-amino acids, including nonproteinogenic amino acid isovaline (Iva), were discovered in the Murchison meteorite, but the detailed molecular mechanism responsible for the observed ee of amino acids remains elusive and inconsistent, because Iva has an inverted circular dichroism (CD) spectrum with respect to α-H amino acids, e.g., alanine. To address this issue, we resort to accurate ab initio calculations for amino acids and their precursors in the Strecker synthesis. We evaluated their photolysis-induced ee in the range 5−11 eV including the Lyman alpha emission line (Lyα), the typical intensive 10.2 eV radiation ascribed to the early phase of galactic evolution. We show that only the aminonitrile precursors are characterized by positive ee in the Lyα region, explaining why right-handed circularly polarized Lyα (R-CPLyα) induces homologous L-amino acids. This study shows that the homochirality of amino acids is produced at the aminonitrile precursors stage.
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Dates et versions

hal-04050544 , version 1 (29-03-2023)

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Mitsuo Shoji, Yuya Kitazawa, Akimasa Sato, Natsuki Watanabe, Mauro Boero, et al.. Enantiomeric Excesses of Aminonitrile Precursors Determine the Homochirality of Amino Acids. Journal of Physical Chemistry Letters, 2023, 14, pp.3243-3248. ⟨10.1021/acs.jpclett.2c03862⟩. ⟨hal-04050544⟩
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