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Article Dans Une Revue Chemical Communications Année : 2023

Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide

Résumé

The solventless synthesis of an amide was performed in a twinscrew extruder in the presence of a coupling agent, providing a high yielding and productive method. The reaction conditions were optimized to prepare APIs, teriflunomide and moclobemide.
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Dates et versions

hal-04032659 , version 1 (16-03-2023)

Identifiants

Citer

Matthieu Lavayssiere, Frédéric Lamaty. Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide. Chemical Communications, 2023, 59 (23), pp.3439-3442. ⟨10.1039/d2cc06934b⟩. ⟨hal-04032659⟩
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