Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide
Résumé
The solventless synthesis of an amide was performed in a twinscrew extruder in the presence of a coupling agent, providing a high yielding and productive method. The reaction conditions were optimized to prepare APIs, teriflunomide and moclobemide.
| Origine | Publication financée par une institution |
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