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Article Dans Une Revue Angewandte Chemie International Edition Année : 2023

Regio‐ and Stereoselective Hydroelementation of SF5‐Alkynes and Further Functionalizations

Résumé

Herein is described a fully regio-and stereoselective hydroelementation reaction of SF5-alkynes with N, O and Snucleophiles and further functionalization of the corresponding Z-(hetero)vinyl-SF5 intermediates, a suitable platform to access α-SF5 ketones and esters, β-SF5 amines and alcohols under mild reaction conditions. Experimental and computational comparative studies between SF5-and CF3-alkynes have been performed to highlight and explain the difference of reactivity and selectivity observed between these two fluorinated motifs.

Domaines

Chimie organique
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Dates et versions

hal-04022814 , version 1 (10-03-2023)

Identifiants

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Lucas Popek, Jorge Juan Cabrera-Trujillo, Vincent Debrauwer, Nicolas Blanchard, Karinne Miqueu, et al.. Regio‐ and Stereoselective Hydroelementation of SF5‐Alkynes and Further Functionalizations. Angewandte Chemie International Edition, 2023, 62 (19), pp.e202300685. ⟨10.1002/anie.202300685⟩. ⟨hal-04022814⟩
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