Regio‐ and Stereoselective Hydroelementation of SF5‐Alkynes and Further Functionalizations
Résumé
Herein is described a fully regio-and stereoselective hydroelementation reaction of SF5-alkynes with N, O and Snucleophiles and further functionalization of the corresponding Z-(hetero)vinyl-SF5 intermediates, a suitable platform to access α-SF5 ketones and esters, β-SF5 amines and alcohols under mild reaction conditions. Experimental and computational comparative studies between SF5-and CF3-alkynes have been performed to highlight and explain the difference of reactivity and selectivity observed between these two fluorinated motifs.
Domaines
Chimie organiqueOrigine | Fichiers produits par l'(les) auteur(s) |
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