Altricial Bird Early-Stage Embryos Express the Molecular “Machinery” to Respond to and Modulate Maternal Thyroid Hormone Cues - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Physiological and Biochemical Zoology Année : 2022

Altricial Bird Early-Stage Embryos Express the Molecular “Machinery” to Respond to and Modulate Maternal Thyroid Hormone Cues

Résumé

Maternal hormones, such as thyroid hormones (THs) trans- ferred to embryos and eggs, are key signaling pathways for mediating maternal effects. To be able to respond to maternal cues, embryos must express the key molecular “machinery” of hormone pathways, such as enzymes and receptors. While altricial birds begin TH production only at or after hatching, experimental evidence suggests that their phenotype can be influenced by maternal THs deposited into the egg. However, it is not understood how or when altricial birds express genes in the TH pathway. For the first time, we measured the expression of key TH-pathway genes in altricial embryos by using two common altricial ecological model species, pied flycatcher (Ficedula hypoleuca) and blue tit (Cyanistes caeruleus). Deiodinase DIO1 gene expression could not be reliably confirmed in either species, but deiodinase enzyme genes DIO2 and DIO3 were ex- pressed in both species. Given that DIO2 converts thyroxine to biologically active triiodothyronine and that DIO3 mostly con- verts triiodothyronine to inactive forms of THs, our results sug- gest that embryos may modulate maternal signals. TH receptors (THRA and THRB) and a monocarboxylate membrane transporter gene (SLC16A2) were also expressed, enabling TH responses. Our results suggest that altricial embryos may be able to re- spond to and potentially modulate maternal signals conveyed by THs in early development.
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hal-03977260 , version 1 (07-02-2023)

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Suvi Ruuskanen, Mickaela Hukkanen, Natacha Garcin, Nina Cossin-Sevrin, Bin‐yan Hsu, et al.. Altricial Bird Early-Stage Embryos Express the Molecular “Machinery” to Respond to and Modulate Maternal Thyroid Hormone Cues. Physiological and Biochemical Zoology, 2022, 95 (6), pp.544-550. ⟨10.1086/721556⟩. ⟨hal-03977260⟩
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