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Article Dans Une Revue Scientific Reports Année : 2015

Gamma oscillations in V1 are correlated with GABAA receptor density: A multi-modal MEG and Flumazenil-PET study

Résumé

High-frequency oscillations in the gamma-band reflect rhythmic synchronization of spike timing in active neural networks. The modulation of gamma oscillations is a widely established mechanism in a variety of neurobiological processes, yet its neurochemical basis is not fully understood. Modeling, in-vitro and in-vivo animal studies suggest that gamma oscillation properties depend on GABAergic inhibition. In humans, search for evidence linking total GABA concentration to gamma oscillations has led to promising -but also to partly diverging- observations. Here, we provide the first evidence of a direct relationship between the density of GABA A receptors and gamma oscillatory gamma responses in human primary visual cortex (V1). By combining Flumazenil-PET (to measure resting-levels of GABA A receptor density) and MEG (to measure visually-induced gamma oscillations), we found that GABA A receptor densities correlated positively with the frequency and negatively with amplitude of visually-induced gamma oscillations in V1. Our findings demonstrate that gamma-band response profiles of primary visual cortex across healthy individuals are shaped by GABA A -receptor-mediated inhibitory neurotransmission. These results bridge the gap with in-vitro and animal studies and may have future clinical implications given that altered GABAergic function, including dysregulation of GABA A receptors, has been related to psychiatric disorders including schizophrenia and depression.
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hal-03962894 , version 1 (30-01-2023)

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Jan Kujala, Julien Jung, Sandrine Bouvard, Françoise Lecaignard, Amélie Lothe, et al.. Gamma oscillations in V1 are correlated with GABAA receptor density: A multi-modal MEG and Flumazenil-PET study. Scientific Reports, 2015, 5 (1), pp.16347. ⟨10.1038/srep16347⟩. ⟨hal-03962894⟩
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