Small anticancer drug release by light: Photochemical internalization of porphyrin-β-cyclodextrin nanoparticles - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Carbohydrate Polymers Année : 2023

Small anticancer drug release by light: Photochemical internalization of porphyrin-β-cyclodextrin nanoparticles

Résumé

Aiming to engineer simple, neutral, strongly amphiphilic photoactive nanoparticles (NPs) to specifically target cancer cell lysosomes for drug transport and light-controlled release, new conjugates of β-cyclodextrin with highly hydrophobic triphenylporphyrin bearing different alkyl chains, were synthesized. Although differently sized, all conjugates self-assemble into ~60 nm NPs in water and display similar photoactivity. The NPs target selectively the lysosomes of breast adenocarcinoma MCF-7 cells, embedding in vesicular membranes, as experiments with model liposomes indicate. Either empty or drug-loaded, the NPs lack dark toxicity for 48 h. They bind with differently structured anticancer drugs tamoxifen and gemcitabine as its N-adamantyl derivative. Red light irradiation of cells incubated with drug-loaded NPs results in major reduction of viability (>85 %) for 48 h displaying significant synergy of photo-chemotoxicity, as opposed to empty NPs, and to loaded non-irradiated NPs, in manifestation of photochemical internalization (PCI). Our approach expands the field of PCI into different small molecule chemotherapeutics.
Fichier principal
Vignette du fichier
Porphyrin-CD_conjugates_FINAL_preprint.pdf (834.3 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03949810 , version 1 (20-01-2023)

Identifiants

Citer

Stylianos Panagiotakis, Barbara Mavroidi, Alexandros Athanasopoulos, Antonio Ricardo Gonçalves, Loïc Bugnicourt-Moreira, et al.. Small anticancer drug release by light: Photochemical internalization of porphyrin-β-cyclodextrin nanoparticles. Carbohydrate Polymers, 2023, 306, pp.120579. ⟨10.1016/j.carbpol.2023.120579⟩. ⟨hal-03949810⟩
25 Consultations
50 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More