Ribonucleoprotein transport in Negative Strand RNA viruses - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biology of the Cell Année : 2023

Ribonucleoprotein transport in Negative Strand RNA viruses

Résumé

Negative-sense, single-stranded RNA (-ssRNA) viruses comprise some of the deadliest human pathogens (Ebola, rabies, influenza A viruses etc.). Developing therapeutic tools relies on a better understanding of their multiplication cycle. For these viruses, the genome replication and transcription activities most-often segregate in membrane-less environments called inclusion bodies (IBs) or viral factories. These “organelles” usually locate far from the cell surface from where new virions are released, and -ssRNA viruses do not encode for transport factors. The efficient trafficking of the genome progeny toward the cell surface is most often ensured by mechanisms co-opting the cellular machineries. In this review, for each -ssRNA viral family, we cover the methods employed to characterize these host-virus interactions, the strategies used by the viruses to promote the virus genome transport, and the current gaps in the literature. Finally, we highlight how Rab11 has emerged as a target of choice for the intracellular transport of -ssRNA virus genomes.
Fichier principal
Vignette du fichier
Biology of the Cell - 2022 - Diot - Ribonucleoprotein transport in Negative Strand RNA viruses.pdf (1000.48 Ko) Télécharger le fichier
Origine : Accord explicite pour ce dépôt
Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification

Dates et versions

hal-03949615 , version 1 (07-02-2023)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Cédric Diot, Gina Cosentino, Marie Anne Rameix-Welti. Ribonucleoprotein transport in Negative Strand RNA viruses. Biology of the Cell, 2023, 115 (1), ⟨10.1111/boc.202200059⟩. ⟨hal-03949615⟩
18 Consultations
20 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More