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Journal Articles Biology of the Cell Year : 2023

Ribonucleoprotein transport in Negative Strand RNA viruses


Negative-sense, single-stranded RNA (-ssRNA) viruses comprise some of the deadliest human pathogens (Ebola, rabies, influenza A viruses etc.). Developing therapeutic tools relies on a better understanding of their multiplication cycle. For these viruses, the genome replication and transcription activities most-often segregate in membrane-less environments called inclusion bodies (IBs) or viral factories. These “organelles” usually locate far from the cell surface from where new virions are released, and -ssRNA viruses do not encode for transport factors. The efficient trafficking of the genome progeny toward the cell surface is most often ensured by mechanisms co-opting the cellular machineries. In this review, for each -ssRNA viral family, we cover the methods employed to characterize these host-virus interactions, the strategies used by the viruses to promote the virus genome transport, and the current gaps in the literature. Finally, we highlight how Rab11 has emerged as a target of choice for the intracellular transport of -ssRNA virus genomes.
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hal-03949615 , version 1 (07-02-2023)


Attribution - NonCommercial - NoDerivatives



Cédric Diot, Gina Cosentino, Marie Anne Rameix-Welti. Ribonucleoprotein transport in Negative Strand RNA viruses. Biology of the Cell, 2023, 115 (1), ⟨10.1111/boc.202200059⟩. ⟨hal-03949615⟩
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