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Article Dans Une Revue Nature Communications Année : 2017

Task Engagement Enhances Population Encoding of Stimulus Meaning in Primary Auditory Cortex

Diego Elgueda
  • Fonction : Auteur
Stephen David
Jonathan Fritz
  • Fonction : Auteur
Pingbo Yin
  • Fonction : Auteur
Shihab Shamma
  • Fonction : Auteur
Yves Boubenec
Srdjan Ostojic

Résumé

Abstract Primary sensory cortices are classically considered to extract and represent stimulus features, while association and higher-order areas are thought to carry information about stimulus meaning. Here we show that this information can in fact be found in the neuronal population code of the primary auditory cortex (A1). A1 activity was recorded in awake ferrets while they either passively listened or actively discriminated stimuli in a range of Go/No-Go paradigms, with different sounds and reinforcements. Population-level dimensionality reduction techniques reveal that task engagement induces a shift in stimulus encoding from a sensory to a behaviorally driven representation that specifically enhances the target stimulus in all paradigms. This shift partly relies on task-engagement-induced changes in spontaneous activity. Altogether, we show that A1 population activity bears strong similarities to frontal cortex responses. These findings indicate that primary sensory cortices implement a crucial change in the structure of population activity to extract task-relevant information during behavior.

Domaines

Neurobiologie
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Dates et versions

hal-03923652 , version 1 (04-01-2023)

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Sophie Bagur, Martin Averseng, Diego Elgueda, Stephen David, Jonathan Fritz, et al.. Task Engagement Enhances Population Encoding of Stimulus Meaning in Primary Auditory Cortex. Nature Communications, 2017, 9 (1), pp.2529. ⟨10.1101/240556⟩. ⟨hal-03923652⟩
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