Abstract This article presents the results of the archaeological, bioanthropological, and historical analysis of an atypical human bone deposit found at the medieval Islamic desert site of Khirbat al-Dusaq in southern present-day Jordan. This site has yielded several human remains deposits, most of which appear to be either ordinary or reorganised burials with a clearly identifiable sepulchral function. However, one particular deposit (labelled “Structure no 1 (Pièce 5)”) displays several atypical features which complicate its interpretation. As such, radiocarbon dating of this particular deposit indicates a chronological range extending from the second half of the seventeenth century CE to the end of the eighteenth century CE. In addition, the human bones contained within this deposit tend to show unusual osteological characteristics, such as possible cut marks resembling peri-mortem lesions inflicted upon the deceased by third parties armed with sharp objects. The precise historical contextualisation of this deposit enables us to discuss different scenarios that could explain the circumstances of its inception. In this sense, the spectrum of possible explanatory interpretations ranges from the conjecture that the remains under study represent one or several victims of an inter-tribal conflict, a brigandage or retaliation attack, a crushed popular uprising, or even individuals who died during one of the violent raids perpetrated by local Bedouin tribes against the Mecca pilgrimage caravans during the Ottoman period.