Electrophile promoted cyclization of \textitortho -aryl substituted ynamides: construction of 3-amino-4-halo- or 4 seleno-isocoumarin derivatives - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2021

Electrophile promoted cyclization of \textitortho -aryl substituted ynamides: construction of 3-amino-4-halo- or 4 seleno-isocoumarin derivatives

Résumé

Isocoumarins are important building blocks in medicinal chemistry. An access to 3-amino-4-halo- or 4-seleno-isocoumarins in a short time (\textless1 min) with good yields was reported via an electrophilic cyclization of ortho -ynamidyl benzoate esters. , Isocoumarins are important building blocks in medicinal chemistry. They are widespread in the core structure of biologically active compounds. Here we report the development of an efficient and highly reactive electrophilic cyclization of ortho -ynamidyl benzoate esters providing access to 3-amino-4-halo- or 4-seleno-isocoumarins in a short time (\textless1 min) with good yields.

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Dates et versions

hal-03871075 , version 1 (25-11-2022)

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Loïc Habert, Iryna Diachenko, Pascal Retailleau, Isabelle Gillaizeau. Electrophile promoted cyclization of \textitortho -aryl substituted ynamides: construction of 3-amino-4-halo- or 4 seleno-isocoumarin derivatives. Organic & Biomolecular Chemistry, 2021, 19 (30), pp.6623-6627. ⟨10.1039/D1OB01075A⟩. ⟨hal-03871075⟩
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