Electrophile promoted cyclization of \textitortho -aryl substituted ynamides: construction of 3-amino-4-halo- or 4 seleno-isocoumarin derivatives
Résumé
Isocoumarins are important building blocks in medicinal chemistry. An access to 3-amino-4-halo- or 4-seleno-isocoumarins in a short time (\textless1 min) with good yields was reported via an electrophilic cyclization of ortho -ynamidyl benzoate esters. , Isocoumarins are important building blocks in medicinal chemistry. They are widespread in the core structure of biologically active compounds. Here we report the development of an efficient and highly reactive electrophilic cyclization of ortho -ynamidyl benzoate esters providing access to 3-amino-4-halo- or 4-seleno-isocoumarins in a short time (\textless1 min) with good yields.