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Article Dans Une Revue European Journal of Organic Chemistry Année : 2022

Synthesis and Studies of Potential Inhibitors of CD73 Based on a Triazole Scaffold

Résumé

The ecto-5′-nucleotidase CD73 is involved in the production of immunosuppressive adenosine in the tumoral microenvironment and recently became a validated target in immuno-oncology. To avoid formation of CD73-produced adenosine, several series of potential inhibitors of the target enzyme based on a triazole scaffold were synthetized and evaluated on recombinant purified hCD73 and in cell-based assays.
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Dates et versions

hal-03842146 , version 1 (07-11-2022)

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Félix Grosjean, Emeline Cros-Perrial, Abdenour Braka, Jean-Pierre Uttaro, Laurent Chaloin, et al.. Synthesis and Studies of Potential Inhibitors of CD73 Based on a Triazole Scaffold. European Journal of Organic Chemistry, 2022, 2022 (21), ⟨10.1002/ejoc.202101175⟩. ⟨hal-03842146⟩
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