Synthesis and Studies of Potential Inhibitors of CD73 Based on a Triazole Scaffold
Résumé
The ecto-5′-nucleotidase CD73 is involved in the production of immunosuppressive adenosine in the tumoral microenvironment and recently became a validated target in immuno-oncology. To avoid formation of CD73-produced adenosine, several series of potential inhibitors of the target enzyme based on a triazole scaffold were synthetized and evaluated on recombinant purified hCD73 and in cell-based assays.
| Origine | Fichiers produits par l'(les) auteur(s) |
|---|