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Article Dans Une Revue Marine drugs Année : 2022

Carotenoids from Marine Microalgae as Antimelanoma Agents

Raphaël Grougnet
  • Fonction : Auteur
Elodie Nicolau
  • Fonction : Auteur
Laurent Picot
Raimundo Gonçalves de Oliveira Junior

Résumé

Melanoma cells are highly invasive and metastatic tumor cells and commonly express molecular alterations that contribute to multidrug resistance (e.g., BRAFV600E mutation). Conventional treatment is not effective in a long term, requiring an exhaustive search for new alternatives. Recently, carotenoids from microalgae have been investigated as adjuvant in antimelanoma therapy due to their safety and acceptable clinical tolerability. Many of them are currently used as food supplements. In this review, we have compiled several studies that show microalgal carotenoids inhibit cell proliferation, cell migration and invasion, as well as induced cell cycle arrest and apoptosis in various melanoma cell lines. MAPK and NF-ĸB pathway, MMP and apoptotic factors are frequently affected after exposure to microalgal carotenoids. Fucoxanthin, astaxanthin and zeaxanthin are the main carotenoids investigated, in both in vitro and in vivo experimental models. Preclinical data indicate these compounds exhibit direct antimelanoma effect but are also capable of restoring melanoma cells sensitivity to conventional chemotherapy (e.g., vemurafenib and dacarbazine).

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Cancer
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hal-03838134 , version 1 (05-11-2022)

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Christiane Adrielly Alves Ferraz, Raphaël Grougnet, Elodie Nicolau, Laurent Picot, Raimundo Gonçalves de Oliveira Junior. Carotenoids from Marine Microalgae as Antimelanoma Agents. Marine drugs, 2022, 20 (10), pp.618. ⟨10.3390/md20100618⟩. ⟨hal-03838134⟩

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