In this paper, an experimental study is presented investigating the influence of cyclic displacement amplitude and effective consolidation stress on the evolution of mobilized local shaft friction along piles submitted to large number of cycles (up to 10 5 cycles). Two-way cyclic displacement-controlled tests were performed on an instrumented pileprobe installed and loaded in a calibration chamber. Tests were performed on reconstituted specimens of saturated clay to examine the shaft friction evolution in the soil-pile interface during cyclic loading. Displacement-controlled static tests were also performed before and after the cyclic loading in order to quantify the influence of cyclic parameters on post-cyclic static response. It was found that the amplitude of cyclic displacement and the initial state of stress have an influence on the evolution of local friction during cyclic loading. The degradation rate of local friction increased for larger cyclic displacement amplitudes whereas with increasing the effective consolidation stress, the degradation rate decreased. The application of displacement-controlled cycles resulted in a modification in the behavior of the interface. A significant peak of static friction followed by strain softening was observed during post cyclic static tests, which was not the case for pre-cyclic static tests. The peak value of friction obtained upon post-cyclic static loadings found to be more important for higher values of applied displacement amplitude during cyclic loading. Finally, a brief synthesis of the results is presented.