A multi-scale epidemic model of enteric infection with heterogeneous shedding resulting from host-microbiota-pathogen interactions
Résumé
Enteric pathogens colonize the digestive tract of farm livestock, such as chickens or pigs and potentially infect food products, which results in a threat for human health and important economic losses. It has been shown that the ability to excrete the pathogen in the environment and contaminate other animals is variable. This heterogeneity in pathogen carriage and shedding results from interactions between the host’s immune response, the pathogen and the commensal intestinal microbiota and plays and important role in epidemic propagation and control. The objective here is to propose a theoretical model of pathogen excretion and transmission linking within and between host dynamic.
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