This chapter addresses the integration and orchestration of external analysis tools into modelling environments. We first give a detailed overview of the considered context and problem statement. Then, a solution in the form of a reference architecture for the integration of analysis tools into modelling environments is presented. We collect a set of requirements that analysis tools must satisfy in order to enable (a) the integration of these analyses into modelling environments and (b) the orchestration of these analysis tools to produce overall results. Finally, we give an overview of different orchestration strategies for the integration of analysis tools and show examples. This core chapter addresses Challenge 2 introduced in Chap. 3 of this book (the practical implications-how to integrate and orchestrate existing analysis tools).