We report the first INTEGRAL timing and spectral analysis of the high mass X-ray binary source 2S 0114+65 at high energies (5-100 keV). The pulse period was found at 2.668 h with a high pulsed fraction, 80% in both the 20-40 keV and 40-80 keV energy bands. The spin-up trend over 8 years was measured to be dot P = -8.9 × 10^-7 s s^-1. The hard X-ray spectrum obtained with JEM-X/ISGRI is well described by a high energy exponential cut-off power law model where the estimated luminosity is 1.8 × 10³⁶ erg s^-1 in the 5-100 keV energy band, for a source distance of 7.2 kpc. We tentatively identify a cyclotron resonance scattering feature at 22 keV with one harmonic, implying a magnetic field of 2.5 × 10¹² G.