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Chapitre D'ouvrage Année : 2022

Off-the-Shelf Allogeneic CAR-T Cells or Other Immune Effector Cells

Waseem Qasim
  • Fonction : Auteur

Résumé

Abstract “Off-the-shelf” allogeneic CAR TCRab T cells and other immune effector cells, such as natural killer (NK) or gamma delta (gd) T cells, can be premanufactured from healthy donors and may offer alternatives to autologous strategies. However, major barriers, namely HLA disparity resulting in graft versus host disease (GvHD) and host-mediated rejection, must be addressed.

Dates et versions

hal-03784072 , version 1 (22-09-2022)

Identifiants

Citer

Stéphane Depil, Waseem Qasim. Off-the-Shelf Allogeneic CAR-T Cells or Other Immune Effector Cells. The EBMT/EHA CAR-T Cell Handbook, Springer International Publishing, pp.51-54, 2022, ⟨10.1007/978-3-030-94353-0_9⟩. ⟨hal-03784072⟩
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