Off-the-Shelf Allogeneic CAR-T Cells or Other Immune Effector Cells
Résumé
Abstract “Off-the-shelf” allogeneic CAR TCRab T cells and other immune effector cells, such as natural killer (NK) or gamma delta (gd) T cells, can be premanufactured from healthy donors and may offer alternatives to autologous strategies. However, major barriers, namely HLA disparity resulting in graft versus host disease (GvHD) and host-mediated rejection, must be addressed.