Hetero-Diels–Alder click reaction of dithioesters for a catalyst-free indirect 18 F-radiolabelling of peptides
Résumé
The HDA reaction of dithioesters was developed as a new click-
reaction compatible with the indirect 18
F-labelling of peptides. It
involves dithioester-peptides and a radiofluorinated diene as a novel
prosthetic group. The method was applied to a PSMA-ligand for the
in vivo detection of LNCap tumors in xenografted mice
Domaines
Autre
Origine : Publication financée par une institution