With the increasing complexity of digital applications, the use of variable-length instruction sets became essential, in order to achieve higher code density and thus better performance. However, security aspects must always be considered, in particular with the significant improvement of attack techniques and equipment. Fault injection, in particular, is among the most interesting and promising attack techniques thanks to the recent advancements. In this article, we provide proper characterization, at the instruction set architecture (ISA) level, for several faulty behaviors that can be obtained when targeting a variable-length instruction set. We take into account the binary encoding of instructions, and show how the obtained behaviors depend on the alignment of the instructions in the memory. Moreover, we are also able to give a better insight on previous results from the literature, that were still partially unexplained. We also show how the observed behaviors can be e
 xploited in various security contexts.