The Risk of Thrombosis Around Pregnancy: Where Do We Stand? - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Frontiers in Cardiovascular Medicine Année : 2022

The Risk of Thrombosis Around Pregnancy: Where Do We Stand?

Résumé

Pregnancy and puerperium increase the relative risk of venous thromboembolism (VTE) and the absolute risk remains low, around 1 per 1,000, with induced mortality of around 1 per 100,000. Analysis of large databases has helped specify the modes of presentation and risk factors (RF) whose impact is greater after than before childbirth, since VTE during pregnancy and post-partum obey different RFs. The evolution of the population concerned (mostly women over 35, obese, of multi-ethnicity undergoing medically assisted reproduction) affects the frequency of these RFs. Pulmonary embolism (PE) is over-represented after childbirth, but 30% of PE in pregnancy occurs without any RFs. Recommendations for prevention, mainly from expert groups, are heterogeneous and often discordant. Low molecular weight heparins (LMWH) are the mainstay of pharmacological thromboprophylaxis, in a field where randomized controlled studies are definitely lacking. VTE risk assessment in pregnancy must be systematic and repetitive. Risk assessment methods and scores are beginning to emerge to guide thromboprophylaxis and should be used more systematically. In the future, analyzing observational data from huge, nationwide registries and prospective cluster clinical trials may bring to light clinically relevant outcomes likely to feed comprehensive guidelines.
Fichier principal
Vignette du fichier
fcvm-09-901869 (1).pdf (525.88 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-03701543 , version 1 (22-06-2022)

Licence

Paternité

Identifiants

Citer

Jean-Christophe Gris, Florence Guillotin, Mathias Chéa, Chloé Bourguignon, Sylvie Bouvier. The Risk of Thrombosis Around Pregnancy: Where Do We Stand?. Frontiers in Cardiovascular Medicine, 2022, 9, pp.901869. ⟨10.3389/fcvm.2022.901869⟩. ⟨hal-03701543⟩
7 Consultations
19 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More